The current status and future trends of BET research in oncology
Siying Yu,
Linna Long,
Xiaorui Zhang,
Yu Qiu,
Yabo Huang,
Xueying Huang,
Xia Li,
Rong Xu,
Chunmei Fan,
He Huang
Affiliations
Siying Yu
Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, China
Linna Long
Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, China
Xiaorui Zhang
Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, China
Yu Qiu
Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, China
Yabo Huang
Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, China
Xueying Huang
Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, China
Xia Li
Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, China; Department of gynaecology, Xinjiang Cancer Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China; People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China
Rong Xu
Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, China
Chunmei Fan
Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, China; Corresponding author.
He Huang
Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, China; Department of gynaecology, Xinjiang Cancer Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China; Corresponding author. Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, China.
Background: BET family proteins are important epigenetic and transcriptional regulators involved in the control of tumorigenesis and development and have become important targets for cancer therapy. However, there is no systematic bibliometric analysis in this field. A visual analysis of the research hotspots and trends of BET is helpful to understand the future development direction. Method: We used CiteSpace, VOSviewer, and Excel to visualize and analyze the trends regarding authors, journals, countries or regions, highly cited papers, and keywords in the field. Result: The results included a total of 946 publications. There are many more papers on BET proteins published since 2013. The papers are mainly from 44 countries, led by the U.S. and China. A total of 7381 authors were identified, among which Bradner, J.E. had the greatest number of articles and the greatest influence. Cancer Discovery was the journal with the most citations per article. Our analysis identified the most influential papers in the field, including highly cited papers and citation burst references. The most frequent keywords included ‘expression’, ‘c-Myc’, ‘cancer’, ‘BRD4’, ‘BET inhibition’, ‘resistance’, ‘differentiation’, and ‘JQ1’, which represent the focus of current and developing research fields. Conclusion: Research on BET is thriving. Collaboration and exchanges between countries and institutions must be strengthened in the future, and the mechanisms of BET-related pathways, the relationship between BET and various diseases, and the development of new BET inhibitors have become the major focus of current research and the trend of future research.
