Brain Research Bulletin (Apr 2022)
Parietal intrahemispheric source connectivity of resting-state electroencephalographic alpha rhythms is abnormal in Naïve HIV patients
- Claudio Babiloni,
- Claudio Del Percio,
- Roberta Lizio,
- Susanna Lopez,
- Alfredo Pennica,
- Paolo Roma,
- Valentina Correr,
- Federica Cucciolla,
- Ginevra Toma,
- Andrea Soricelli,
- Francesco Di Campli,
- Antonio Aceti,
- Elisabetta Teti,
- Loredana Sarmati,
- Gloria Crocetti,
- Raffaele Ferri,
- Ivan Lorenzo,
- Massimo Galli,
- Cristina Negri,
- Gioacchino Angarano,
- Annalisa Saracino,
- Luciana Lepore,
- Massimo Di Pietro,
- Francesco Maria Fusco,
- Vincenzo Vullo,
- Gabriella D’Ettorre,
- Pasquale Pagliano,
- Giusy Di Flumeri,
- Benedetto Maurizio Celesia,
- Elio Gentilini Cacciola,
- Giovanni Di Perri,
- Andrea Calcagno,
- Fabrizio Stocchi,
- Stefano Ferracuti,
- Paolo Onorati,
- Massimo Andreoni,
- Giuseppe Noce
Affiliations
- Claudio Babiloni
- Department of Physiology and Pharmacology “Erspamer”, Sapienza University of Rome, Rome, Italy; Hospital San Raffaele Cassino, Cassino (FR), Italy; Correspondence to: Department of Physiology and Pharmacology ''V. Erspamer'', Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.
- Claudio Del Percio
- Department of Physiology and Pharmacology “Erspamer”, Sapienza University of Rome, Rome, Italy
- Roberta Lizio
- IRCCS Synlab SDN, Naples, Italy
- Susanna Lopez
- Department of Physiology and Pharmacology “Erspamer”, Sapienza University of Rome, Rome, Italy
- Alfredo Pennica
- Infectious Diseases, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy
- Paolo Roma
- Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy
- Valentina Correr
- Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy
- Federica Cucciolla
- Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy
- Ginevra Toma
- Department of Physiology and Pharmacology “Erspamer”, Sapienza University of Rome, Rome, Italy
- Andrea Soricelli
- IRCCS Synlab SDN, Naples, Italy; Department of Motor Sciences and Healthiness, University of Naples Parthenope, Naples, Italy
- Francesco Di Campli
- Infectious Diseases, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy
- Antonio Aceti
- Infectious Diseases, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy
- Elisabetta Teti
- Clinical Infectious Diseases, University of Rome “Tor Vergata”, Rome, Italy
- Loredana Sarmati
- Clinical Infectious Diseases, University of Rome “Tor Vergata”, Rome, Italy
- Gloria Crocetti
- Infectious Diseases, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy
- Raffaele Ferri
- Oasi Research Institute - IRCCS, Troina, Italy
- Ivan Lorenzo
- Oasi Research Institute - IRCCS, Troina, Italy
- Massimo Galli
- Luigi Sacco Hospital, University of Milan, Milan, Italy
- Cristina Negri
- Luigi Sacco Hospital, University of Milan, Milan, Italy
- Gioacchino Angarano
- Clinic of Infectious Diseases, Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, Italy
- Annalisa Saracino
- Clinic of Infectious Diseases, Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, Italy
- Luciana Lepore
- Clinic of Infectious Diseases, Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, Italy
- Massimo Di Pietro
- Santa Maria Annunziata Hospital, Florence, Italy
- Francesco Maria Fusco
- Santa Maria Annunziata Hospital, Florence, Italy
- Vincenzo Vullo
- Umberto I Hospital, Rome, Italy
- Gabriella D’Ettorre
- Umberto I Hospital, Rome, Italy
- Pasquale Pagliano
- Department of Medicine, Surgery and Dentistry, ''Scuola Medica Salernitana'', Unit of Infectious Diseases, University of Salerno, Baronissi, Italy
- Giusy Di Flumeri
- AORN dei Colli, D. Cotugno Hospital, Department of Infectious Disease and Infectious Emergencies, Naples, Italy
- Benedetto Maurizio Celesia
- Unit of Infectious Diseases, Garibaldi Hospital, Catania, Italy
- Elio Gentilini Cacciola
- Umberto I Hospital, Rome, Italy
- Giovanni Di Perri
- Amedeo di Savoia Hospital, Turin, Italy
- Andrea Calcagno
- Unit of Infectious Diseases, Department of Medical Sciences, University of Turin, Turin, Italy
- Fabrizio Stocchi
- IRCCS S. Raffaele Pisana, Rome, Italy
- Stefano Ferracuti
- Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy
- Paolo Onorati
- Department of Physiology and Pharmacology “Erspamer”, Sapienza University of Rome, Rome, Italy
- Massimo Andreoni
- Clinical Infectious Diseases, University of Rome “Tor Vergata”, Rome, Italy
- Giuseppe Noce
- IRCCS Synlab SDN, Naples, Italy
- Journal volume & issue
-
Vol. 181
pp. 129 – 143
Abstract
Previous evidence showed abnormal parietal sources of resting-state electroencephalographic (EEG) delta (< 4 Hz) and alpha (8–12 Hz) rhythms in treatment-Naïve HIV (Naïve HIV) subjects, as cortical neural synchronization markers in quiet wakefulness. Here, we tested the hypothesis that these local abnormalities may be related to functional cortical dysconnectivity as an oscillatory brain network disorder.The present EEG database regarded 128 Naïve HIV and 60 Healthy subjects. The eLORETA freeware estimated lagged linear EEG source connectivity (LLC). The area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification between Healthy and HIV individuals.Parietal intrahemispheric LLC solutions in alpha sources were abnormally lower in the Naïve HIV than in the control group. Furthermore, those abnormalities were greater in the Naïve HIV subgroup with executive and visuospatial deficits than the Naïve HIV subgroup with normal cognition. AUROC curves of those LLC solutions exhibited moderate/good accuracies (0.75–0.88) in the discrimination between the Naïve HIV individuals with executive and visuospatial deficits vs. Naïve HIV individuals with normal cognition and control individuals.In quiet wakefulness, Naïve HIV subjects showed clinically relevant abnormalities in parietal alpha source connectivity. HIV may alter a parietal “hub” oscillating at the alpha frequency in quiet wakefulness as a brain network disorder.
