Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases

Vishnu Raman; Nele Van Dessel; Christopher L. Hall; Victoria E. Wetherby; Samantha A. Whitney; Emily L. Kolewe; Shoshana M. K. Bloom; Abhinav Sharma; Jeanne A. Hardy; Mathieu Bollen; Aleyde Van Eynde; Neil S. Forbes

doi:10.1038/s41467-021-26367-9

Nature Communications (Oct 2021)

Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases

Vishnu Raman,
Nele Van Dessel,
Christopher L. Hall,
Victoria E. Wetherby,
Samantha A. Whitney,
Emily L. Kolewe,
Shoshana M. K. Bloom,
Abhinav Sharma,
Jeanne A. Hardy,
Mathieu Bollen,
Aleyde Van Eynde,
Neil S. Forbes

Affiliations

Vishnu Raman: Department of Chemical Engineering, University of Massachusetts, Amherst
Nele Van Dessel: Department of Chemical Engineering, University of Massachusetts, Amherst
Christopher L. Hall: Department of Chemical Engineering, University of Massachusetts, Amherst
Victoria E. Wetherby: Ernest Pharmaceuticals, LLC
Samantha A. Whitney: Department of Chemical Engineering, University of Massachusetts, Amherst
Emily L. Kolewe: Department of Chemical Engineering, University of Massachusetts, Amherst
Shoshana M. K. Bloom: Department of Chemical Engineering, University of Massachusetts, Amherst
Abhinav Sharma: Department of Chemical Engineering, University of Massachusetts, Amherst
Jeanne A. Hardy: Department of Chemistry, University of Massachusetts, Amherst
Mathieu Bollen: Laboratory of Biosignaling & Therapeutics, Department of Cellular and Molecular Medicine, KU Leuven
Aleyde Van Eynde: Laboratory of Biosignaling & Therapeutics, Department of Cellular and Molecular Medicine, KU Leuven
Neil S. Forbes: Department of Chemical Engineering, University of Massachusetts, Amherst

DOI: https://doi.org/10.1038/s41467-021-26367-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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The limited ability of cancer therapeutics in crossing the cancer cell membrane hampers their therapeutic potential. Here, the authors report Salmonella-based system for intracellular delivery of protein drugs, e.g. caspase-3, and show reduction of tumors in mouse models of breast and liver cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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