Penicillium citrinum: Opportunistic pathogen or idle bystander? A case analysis with demonstration of galactomannan cross-reactivity

Shayla E. Hesse; Paul M. Luethy; John H. Beigel; Adrian M. Zelazny

doi:10.1016/j.mmcr.2017.05.003

Medical Mycology Case Reports (Sep 2017)

Penicillium citrinum: Opportunistic pathogen or idle bystander? A case analysis with demonstration of galactomannan cross-reactivity

Shayla E. Hesse,
Paul M. Luethy,
John H. Beigel,
Adrian M. Zelazny

Affiliations

Shayla E. Hesse: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Paul M. Luethy: Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD, USA
John H. Beigel: Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA
Adrian M. Zelazny: Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD, USA

DOI: https://doi.org/10.1016/j.mmcr.2017.05.003
Journal volume & issue: Vol. 17, no. C
pp. 8 – 10

Abstract

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We present a case of an immunocompromised woman with fever, pulmonary infiltrates and multiple bronchoalveolar lavage (BAL) cultures positive for Penicillium citrinum with a concomitant high BAL galactomannan level. We report the results of Aspergillus galactomannan testing performed on culture supernatants from her P. citrinum strain that confirmed the suspected cross-reactivity. Finally, we discuss the clinical significance and antifungal susceptibility of P. citrinum in our case and review the literature.

Published in Medical Mycology Case Reports

ISSN: 2211-7539 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: https://www.journals.elsevier.com/medical-mycology-case-reports/

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