Influence of apolipoprotein E gene polymorphisms on coronary artery disease in patients undergoing coronary angiography
Azhi ShaMa,
Yingying Huang,
Chunlan Ma,
Chunmei Xu,
Jingyue Hu,
Zhuxin Li,
Chunyu Zeng
Affiliations
Azhi ShaMa
Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, PR China
Yingying Huang
Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, PR China
Chunlan Ma
Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, PR China
Chunmei Xu
Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, PR China
Jingyue Hu
Department of Neurology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, PR China
Zhuxin Li
Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, PR China; Chongqing Key Laboratory for Hypertension Research, Chongqing Cardiovascular Clinical Research Center, Chongqing Institute of Cardiology, Chongqing, PR China
Chunyu Zeng
Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, PR China; Chongqing Key Laboratory for Hypertension Research, Chongqing Cardiovascular Clinical Research Center, Chongqing Institute of Cardiology, Chongqing, PR China; State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, PR China; Heart Center of Fujian Province, Union Hospital, Fujian Medical University, Fuzhou, PR China; Department of Cardiology, Chongqing General Hospital, Chongqing, PR China; Cardiovascular Research Center of Chongqing College, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Chongqing, PR China; Corresponding author. Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, PR China.
Objective: Previous studies have shown that apolipoprotein E (ApoE) gene polymorphisms have an impact on coronary artery disease(CAD). However, many studies have small sample sizes and different conclusions. The purpose was to retrospectively study the influence of ApoE gene polymorphisms on CAD. Methods: This study assessed the influence of different ApoE genotypes on coronary heart disease in patients who received coronary angiography and used multivariate logistic regression to assess the influence of different ApoE genotypes on CAD. Results: Patients with different ApoE genotypes had no obvious differences in the incidence of hypertension, diabetes or obesity（P > 0.05). Patients with ε2/ε2 had higher incidence of hypertriglyceridemia than patients with other ApoE genotypes, while patients with ε3/ε3 had a lower incidence of hypertriglyceridemia than those with ε3/ε4,ε4/ε4, ε2/ε3 and ε2/ε2（P 0.05). ε2/ε4 and ε2/ε3 reduced the risk of high LDL-C, and reduced the severity and incidence of coronary heart（P < 0.05). ε2/ε3 reduced risk of premature coronary artery disease（PCAD）（P < 0.05). ε2/ε3 reduced risk of CAD in patients age <45,age at 60–74 and age ≥74, while ε2/ε4 reduced risk of CAD in patients age ≥74（P < 0.05). Conclusion: Patients with ε3/ε4, ε4/ε4,ε3/ε3 and ε2/ε2 had no significant differences in the severity and occurrence of CAD. Compared to the isoform ε3 (ε3/ε3), isoform ε4 did not increased the severity and occurrence of CAD. Compared with ApoE other genotypes, ε2/ε3 and ε2/ε4 reduced the risk of high LDL-C and the severity and occurrence of CAD.
