AIP Advances (Mar 2014)

Piezoresistive measurement of Swine H1N1 Hemagglutinin peptide binding with microcantilever arrays

  • N. Bajwa,
  • C. J. Maldonado,
  • T. Thundat,
  • A. Passian

DOI
https://doi.org/10.1063/1.4869636
Journal volume & issue
Vol. 4, no. 3
pp. 037118 – 037118-6

Abstract

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Effective detection of Swine H1N1 Hemagglutinin peptide is crucial as it could be used as a positive control to screen for highly infectious flu strains such as Swine-Origin Influenza A (H1N1). Piezoresistive microcantilever arrays present a pathway towards highly sensitive and label-free detection of biomolecules by transducing the antigen-antibody binding into change in resistivity via induced surface stress variation. We demonstrate a mechanical transduction of Swine H1N1 Hemagglutinin peptide binding and suggest the employed technique may offer a potential platform for detection of the H1N1 virus, which could be clinically used to diagnose and provide subsequent relief.