Impact of bone density and integrated screw configuration on standalone anterior lumbar interbody construct strength

Abstract

Background: In anterior lumbar interbody fusion (ALIF), the use of integrated screws is attractive to surgeons because of the ease of implantation and no additional profile. However, the number and length of screws necessary for safe and stable implantation in various bone densities is not yet fully understood. The current study aims to determine how important both length and number of screws are for stability of ALIFs. Methods: Three bone models with densities of 10, 15, and 20 pounds per cubic foot (PCF) were chosen as surrogates. These were instrumented using the Z-Link lumbar interbody system with either 2, 3, or 4 integrated 4.5 × 20 mm screws or 4.5 × 25 mm screws (Zavation, LLC, Flowood, MS). The bone surrogates were tested with loading conditions resulting in spine extension to measure construct stiffness and peak force. Results: The failure load of the construct was influenced by the length of screws (p=.01) and density of the bone surrogate (p<.01). There was no difference in failure load between using 2 screws and 3 screws (p=.32) or when using four 20 mm screws versus three 25 mm screws (p=.295). Conclusion: In our study, both bone density and length of screws significantly affected the construct's load to failure. In certain cases where a greater number of screws are unable to be implanted, the same stability can potentially be conferred with use of longer screws. Future clinical studies should be performed to test these biomechanical results.

Keywords

• Anterior lumbar interbody fusion
• Alif
• Osteoporosis
• Screws
• Fusion
• Interbody cages