INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury

Barbara Calabrese; Steven L. Jones; Yoko Shiraishi-Yamaguchi; Michael Lingelbach; Uri Manor; Tatyana M. Svitkina; Henry N. Higgs; Andy Y. Shih; Shelley Halpain

doi:10.1038/s41467-022-33268-y

Nature Communications (Oct 2022)

INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury

Barbara Calabrese,
Steven L. Jones,
Yoko Shiraishi-Yamaguchi,
Michael Lingelbach,
Uri Manor,
Tatyana M. Svitkina,
Henry N. Higgs,
Andy Y. Shih,
Shelley Halpain

Affiliations

Barbara Calabrese: Department of Neurobiology, School of Biological Sciences, University of California, San Diego, and Sanford Consortium for Regenerative Medicine
Steven L. Jones: Department of Biology, University of Pennsylvania
Yoko Shiraishi-Yamaguchi: Japan Science and Technology Agency (JST)
Michael Lingelbach: Neurosciences Interdepartmental Program, Stanford University
Uri Manor: The Salk Institute for Biological Studies
Tatyana M. Svitkina: Department of Biology, University of Pennsylvania
Henry N. Higgs: Department of Biochemistry, Geisel School of Medicine
Andy Y. Shih: Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute
Shelley Halpain: Department of Neurobiology, School of Biological Sciences, University of California, San Diego, and Sanford Consortium for Regenerative Medicine

DOI: https://doi.org/10.1038/s41467-022-33268-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 20

Abstract

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Post injury cytoskeletal modifications in neurons are not fully understood. Here the authors describe a pro-survival actin cytoskeletal reorganization in neurons triggered during a model of ischemic stroke.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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