Real-Time and Ultrasensitive Prostate-Specific Antigen Sensing Using Love-Mode Surface Acoustic Wave Immunosensor Based on MoS<sub>2</sub>@Cu<sub>2</sub>O-Au Nanocomposites
Yan Yu,
Haiyu Xie,
Tao Zhou,
Haonan Zhang,
Chenze Lu,
Ran Tao,
Zhaozhao Tang,
Jingting Luo
Affiliations
Yan Yu
Shenzhen Key Laboratory of Advanced Thin Films and Applications, GuangDong Engineering Technology Research Centre of Breath Test, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
Haiyu Xie
Shenzhen Key Laboratory of Advanced Thin Films and Applications, GuangDong Engineering Technology Research Centre of Breath Test, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
Tao Zhou
Shenzhen Key Laboratory of Advanced Thin Films and Applications, GuangDong Engineering Technology Research Centre of Breath Test, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
Haonan Zhang
Shenzhen Key Laboratory of Advanced Thin Films and Applications, GuangDong Engineering Technology Research Centre of Breath Test, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
Chenze Lu
Key Laboratory of Specialty Agri-Products Quality and Hazard Controlling Technology of Zhejiang Province, College of Life Sciences, China Jiliang University, Hangzhou 310018, China
Ran Tao
Shenzhen Key Laboratory of Advanced Thin Films and Applications, GuangDong Engineering Technology Research Centre of Breath Test, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
Zhaozhao Tang
Water Science and Environmental Engineering Research Centre, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China
Jingting Luo
Shenzhen Key Laboratory of Advanced Thin Films and Applications, GuangDong Engineering Technology Research Centre of Breath Test, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
Prostate-specific antigen (PSA) is a well-established tumour marker for prostatic carcinoma. In this study, we present a novel, real-time, and ultrasensitive Love-mode surface acoustic wave (L-SAW) immunosensor for PSA detection enhanced by MoS2@Cu2O-Au nanocomposite conjugation. The MoS2@Cu2O-Au nanocomposites were analyzed by SEM, XRD, and EDS. The experiments show a significant improvement in sensitivity and detection limit compared with the previous detection methods utilizing nanogold alone to detect PSA biomolecules. The experimental results show a good linear relationship when the range of PSA concentrations between 200 pg/mL and 5 ng/mL was tested. The experimental results also show good specificity against alpha 1 fetoprotein and L-tryptophan disruptors.
