Communications Biology (Jun 2021)

A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome

  • Keiji Kawatani,
  • Toshihiko Nambara,
  • Nobutoshi Nawa,
  • Hidetaka Yoshimatsu,
  • Haruna Kusakabe,
  • Katsuya Hirata,
  • Akira Tanave,
  • Kenta Sumiyama,
  • Kimihiko Banno,
  • Hidetoshi Taniguchi,
  • Hitomi Arahori,
  • Keiichi Ozono,
  • Yasuji Kitabatake

DOI
https://doi.org/10.1038/s42003-021-02242-7
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 15

Abstract

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Keiji Kawatani et al. developed a panel of Down syndrome (DS) isogenic astrocytes derived from iPSCs to observe the consequence of DS on astrocyte precursor proliferation, differentiation, and gene expression. Their results suggest a dose-dependent effect of DYRK1A and PIGP on DS-derived astrocyte precursor proliferation, and represent a valuable resource and cellular model for future DS research.