Frontiers in Cell and Developmental Biology (Feb 2022)
Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence
- Weijun Zhang,
- Weijun Zhang,
- Jinwu Bai,
- Jinwu Bai,
- Kai Hang,
- Kai Hang,
- Jianxiang Xu,
- Jianxiang Xu,
- Chengwei Zhou,
- Chengwei Zhou,
- Lijun Li,
- Lijun Li,
- Zhongxiang Wang,
- Zhongxiang Wang,
- Yibo Wang,
- Yibo Wang,
- Kanbin Wang,
- Kanbin Wang,
- Deting Xue,
- Deting Xue
Affiliations
- Weijun Zhang
- Department of Orthopaedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China
- Weijun Zhang
- Institute of Orthopaedics, School of Medicine, Zhejiang University, Hangzhou, China
- Jinwu Bai
- Department of Orthopaedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China
- Jinwu Bai
- Institute of Orthopaedics, School of Medicine, Zhejiang University, Hangzhou, China
- Kai Hang
- Department of Orthopaedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China
- Kai Hang
- Institute of Orthopaedics, School of Medicine, Zhejiang University, Hangzhou, China
- Jianxiang Xu
- Department of Orthopaedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China
- Jianxiang Xu
- Institute of Orthopaedics, School of Medicine, Zhejiang University, Hangzhou, China
- Chengwei Zhou
- Department of Orthopaedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China
- Chengwei Zhou
- Institute of Orthopaedics, School of Medicine, Zhejiang University, Hangzhou, China
- Lijun Li
- Department of Orthopaedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China
- Lijun Li
- Institute of Orthopaedics, School of Medicine, Zhejiang University, Hangzhou, China
- Zhongxiang Wang
- Department of Orthopaedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China
- Zhongxiang Wang
- Institute of Orthopaedics, School of Medicine, Zhejiang University, Hangzhou, China
- Yibo Wang
- Department of Orthopaedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China
- Yibo Wang
- Institute of Orthopaedics, School of Medicine, Zhejiang University, Hangzhou, China
- Kanbin Wang
- Department of Orthopaedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China
- Kanbin Wang
- Institute of Orthopaedics, School of Medicine, Zhejiang University, Hangzhou, China
- Deting Xue
- Department of Orthopaedics, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China
- Deting Xue
- Institute of Orthopaedics, School of Medicine, Zhejiang University, Hangzhou, China
- DOI
- https://doi.org/10.3389/fcell.2022.817877
- Journal volume & issue
-
Vol. 10
Abstract
Mesenchymal stem cell (MSC) transplantation has been widely used as a potential treatment for a variety of diseases. However, the contradiction between the low survival rate of transplanted cells and the beneficial therapeutic effects has affected its clinical use. Lysosomes as organelles at the center of cellular recycling and metabolic signaling, play essential roles in MSC homeostasis. In the first part of this review, we summarize the role of lysosomal acidification dysfunction in MSC senescence. In the second part, we summarize some of the potential strategies targeting lysosomal proteins to enhance the therapeutic effect of MSCs.
Keywords
