Фармакокинетика и Фармакодинамика (Nov 2017)
Neuroprotective and anticonvulsant effects of Cerebrolysin in the experiment
Abstract
Purpose of the study. Assess anticonvulsant and neuroprotective effects of Cerebrolysin in rats. Material and methods. The study was carried out on 30 white male rats, who received a course of Cerebrolysin. The model of primary-generalized convulsions was reproduced by a single administration of thiosemicarbazide. Results and conclusion. Preliminary introduction of Cerebrolysin reduces the severity and duration of seizures caused by thiosemicarbazide, increases the survival rate of animals. The test drug has a neuroprotective effect on the cells of the cerebral cortex under conditions of ischemia.