Permeability of membranes in the liquid ordered and liquid disordered phases

An Ghysels; Andreas Krämer; Richard M. Venable; Walter E. Teague; Edward Lyman; Klaus Gawrisch; Richard W. Pastor

doi:10.1038/s41467-019-13432-7

Nature Communications (Dec 2019)

Permeability of membranes in the liquid ordered and liquid disordered phases

An Ghysels,
Andreas Krämer,
Richard M. Venable,
Walter E. Teague,
Edward Lyman,
Klaus Gawrisch,
Richard W. Pastor

Affiliations

An Ghysels: Center for Molecular Modeling, Ghent University
Andreas Krämer: Laboratory of Computational Biology, National Heart Lung Blood Institute, National Institutes of Health
Richard M. Venable: Laboratory of Computational Biology, National Heart Lung Blood Institute, National Institutes of Health
Walter E. Teague: Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
Edward Lyman: Department of Physics and Astronomy and Department of Chemistry and Biochemistry, University of Delaware
Klaus Gawrisch: Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
Richard W. Pastor: Laboratory of Computational Biology, National Heart Lung Blood Institute, National Institutes of Health

DOI: https://doi.org/10.1038/s41467-019-13432-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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Increasing evidence supports the existence of ordered nanodomains (or rafts) in cholesterol rich cell membranes. Here authors present molecular dynamics simulations and EPR experiments to monitor permeation of oxygen and water through membranes in the liquid ordered and liquid disordered phases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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