Thymic Regulatory T Cell Development: Role of Signalling Pathways and Transcription Factors

Mark Engel; Tom Sidwell; Ajithkumar Vasanthakumar; George Grigoriadis; Ashish Banerjee

doi:10.1155/2013/617595

Clinical and Developmental Immunology (Jan 2013)

Thymic Regulatory T Cell Development: Role of Signalling Pathways and Transcription Factors

Mark Engel,
Tom Sidwell,
Ajithkumar Vasanthakumar,
George Grigoriadis,
Ashish Banerjee

Affiliations

Mark Engel: Centre for Inflammatory Diseases, Monash Medical Centre, Southern Clinical School, Monash University, Clayton, VIC 3168, Australia
Tom Sidwell: Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia
Ajithkumar Vasanthakumar: Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia
George Grigoriadis: Centre for Inflammatory Diseases, Monash Medical Centre, Southern Clinical School, Monash University, Clayton, VIC 3168, Australia
Ashish Banerjee: Centre for Inflammatory Diseases, Monash Medical Centre, Southern Clinical School, Monash University, Clayton, VIC 3168, Australia

DOI: https://doi.org/10.1155/2013/617595
Journal volume & issue: Vol. 2013

Abstract

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Regulatory T cells (Tregs) are a subset of CD4 T cells that are key mediators of immune tolerance. Most Tregs develop in the thymus. In this review we summarise recent findings on the role of diverse signalling pathways and downstream transcription factors in thymic Treg development.

Published in Clinical and Developmental Immunology

ISSN: 1740-2522 (Print); 1740-2530 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://onlinelibrary.wiley.com/journal/1607

About the journal