Apolipoprotein A-I, A-II, and VLDL-B-100 metabolism in men

Sophie Desroches; Marie-Eve Paradis; Mélanie Pérusse; W. Roodly Archer; Jean Bergeron; Patrick Couture; Nathalie Bergeron; Benoît Lamarche

Journal of Lipid Research (Dec 2004)

Apolipoprotein A-I, A-II, and VLDL-B-100 metabolism in men

Sophie Desroches,
Marie-Eve Paradis,
Mélanie Pérusse,
W. Roodly Archer,
Jean Bergeron,
Patrick Couture,
Nathalie Bergeron,
Benoît Lamarche

Affiliations

Sophie Desroches: Institute on Nutraceuticals and Functional Foods, Laval University, Ste-Foy, Québec, Canada; Department of Food Sciences and Nutrition, Laval University, Québec, Canada; Lipid Research Center, Laval University Medical Research Center, Ste-Foy, Québec, Canada
Marie-Eve Paradis: Institute on Nutraceuticals and Functional Foods, Laval University, Ste-Foy, Québec, Canada; Department of Food Sciences and Nutrition, Laval University, Québec, Canada; Lipid Research Center, Laval University Medical Research Center, Ste-Foy, Québec, Canada
Mélanie Pérusse: Institute on Nutraceuticals and Functional Foods, Laval University, Ste-Foy, Québec, Canada; Department of Food Sciences and Nutrition, Laval University, Québec, Canada; Lipid Research Center, Laval University Medical Research Center, Ste-Foy, Québec, Canada
W. Roodly Archer: Institute on Nutraceuticals and Functional Foods, Laval University, Ste-Foy, Québec, Canada; Department of Food Sciences and Nutrition, Laval University, Québec, Canada; Lipid Research Center, Laval University Medical Research Center, Ste-Foy, Québec, Canada
Jean Bergeron: Institute on Nutraceuticals and Functional Foods, Laval University, Ste-Foy, Québec, Canada; Department of Food Sciences and Nutrition, Laval University, Québec, Canada; Lipid Research Center, Laval University Medical Research Center, Ste-Foy, Québec, Canada
Patrick Couture: Institute on Nutraceuticals and Functional Foods, Laval University, Ste-Foy, Québec, Canada; Department of Food Sciences and Nutrition, Laval University, Québec, Canada; Lipid Research Center, Laval University Medical Research Center, Ste-Foy, Québec, Canada
Nathalie Bergeron: Institute on Nutraceuticals and Functional Foods, Laval University, Ste-Foy, Québec, Canada; Department of Food Sciences and Nutrition, Laval University, Québec, Canada; Lipid Research Center, Laval University Medical Research Center, Ste-Foy, Québec, Canada
Benoît Lamarche: Institute on Nutraceuticals and Functional Foods, Laval University, Ste-Foy, Québec, Canada; Department of Food Sciences and Nutrition, Laval University, Québec, Canada; Lipid Research Center, Laval University Medical Research Center, Ste-Foy, Québec, Canada

Journal volume & issue: Vol. 45, no. 12
pp. 2331 – 2338

Abstract

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The impact of a low-fat diet and a high-MUFA diet on apolipoprotein A-I (apoA-I), apoA-II, and VLDL-apoB-100 metabolism in conditions of unrestricted (ad libitum) energy intake was compared in 65 men randomly assigned to one of two predefined experimental diets. A subsample of 18 men participated in the kinetic study. Before and after the 6–7 week dietary intervention, kinetic subjects received a primed-constant infusion of [5,5,5-2H3]l-leucine for 12 h under feeding conditions. ApoA-I production rate (PR; −31.5%; P < 0.001) and fractional catabolic rate (FCR; −24.3%; P < 0.05) were significantly decreased after the low-fat diet. These changes in apoA-I PR and FCR with the low-fat diet were also significantly different from those observed with the high-MUFA diet (P < 0.01 and P < 0.05, respectively). ApoA-II FCR was significantly increased in the high-MUFA group only. No significant within- or between-diet difference was found in VLDL-apoB-100 PR or FCR.These results emphasize the differential impact of the low-fat diet and high-MUFA diet on HDL metabolism.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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