Kinetics of interaction between polyreactive immunoglobulins and antigen. The theory

Abstract

Dynamics of association between polyreactive immunoglobulins (PRIGs) and immobilized antigens is considered on the base of our model of PRIGs-antigen interaction, which was suggested by us earlier. This process of PRIGs binding to an immobilized antigen was described with a system of differential equations. The solution of this system of differential equations gives mathematical expressions that relate the dynamics of the reactant concentrations and time of the reaction. Using Microsoft Excel program the theoretical curves were calculated and plotted that described the dynamics of “active”, “nonactive” PRIGs in solution as well as PRIGs that were bound to an immobilized antigen. Conclusions drawn by us earlier about very high dependen­ce of reaction PRIGs with an antigen from temperature were confirmed.

Keywords

• kinetics of interaction
• polyreactive immunoglobulins
• rate constants