Nature Communications (Jul 2022)
Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ
- Qian Zhou,
- Wan-Wan Sun,
- Jia-Cong Chen,
- Hui-Lu Zhang,
- Jie Liu,
- Yan Lin,
- Peng-Cheng Lin,
- Bai-Xing Wu,
- Yan-Peng An,
- Lin Huang,
- Wen-Xing Sun,
- Xin-Wen Zhou,
- Yi-Ming Li,
- Yi-Yuan Yuan,
- Jian-Yuan Zhao,
- Wei Xu,
- Shi-Min Zhao
Affiliations
- Qian Zhou
- Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University
- Wan-Wan Sun
- Endocrinology department, Huashan Hospital, 5th affiliated Hospital, Fudan University Shanghai Cancer Center, Fudan University
- Jia-Cong Chen
- Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University
- Hui-Lu Zhang
- Endocrinology department, Huashan Hospital, 5th affiliated Hospital, Fudan University Shanghai Cancer Center, Fudan University
- Jie Liu
- Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University
- Yan Lin
- Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University
- Peng-Cheng Lin
- Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai University for Nationalities
- Bai-Xing Wu
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, RNA Biomedical Institute, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Yan-Peng An
- Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University
- Lin Huang
- Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University
- Wen-Xing Sun
- Department of Nutrition and Food Hygiene, School of Public Health, Nantong University
- Xin-Wen Zhou
- Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University
- Yi-Ming Li
- Endocrinology department, Huashan Hospital, 5th affiliated Hospital, Fudan University Shanghai Cancer Center, Fudan University
- Yi-Yuan Yuan
- Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University
- Jian-Yuan Zhao
- Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University
- Wei Xu
- Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University
- Shi-Min Zhao
- Obstetrics & Gynecology Hospital of Fudan University, State Key Laboratory of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University
- DOI
- https://doi.org/10.1038/s41467-022-32000-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Whether amino acids act on cellular insulin signaling remains unclear. Here, the authors find that phenylalanine modifies insulin receptor beta (IRβ) and inactivates insulin signaling and glucose uptake and positively correlated with T2D onset.
