Nature Communications (Jul 2020)
Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype
- Nicole Thornton,
- Vanja Karamatic Crew,
- Louise Tilley,
- Carole A. Green,
- Chwen Ling Tay,
- Rebecca E. Griffiths,
- Belinda K. Singleton,
- Frances Spring,
- Piers Walser,
- Abdul Ghani Alattar,
- Benjamin Jones,
- Rosalind Laundy,
- Jill R. Storry,
- Mattias Möller,
- Lorna Wall,
- Richard Charlewood,
- Connie M. Westhoff,
- Christine Lomas-Francis,
- Vered Yahalom,
- Ute Feick,
- Axel Seltsam,
- Beate Mayer,
- Martin L. Olsson,
- David J. Anstee
Affiliations
- Nicole Thornton
- International Blood Group Reference Laboratory, NHS Blood and Transplant
- Vanja Karamatic Crew
- International Blood Group Reference Laboratory, NHS Blood and Transplant
- Louise Tilley
- International Blood Group Reference Laboratory, NHS Blood and Transplant
- Carole A. Green
- Bristol Institute for Transfusion Sciences, NHS Blood and Transplant and NIHR Blood and Transplant Unit in Red Cell Products, University of Bristol
- Chwen Ling Tay
- International Blood Group Reference Laboratory, NHS Blood and Transplant
- Rebecca E. Griffiths
- Bristol Institute for Transfusion Sciences, NHS Blood and Transplant and NIHR Blood and Transplant Unit in Red Cell Products, University of Bristol
- Belinda K. Singleton
- Bristol Institute for Transfusion Sciences, NHS Blood and Transplant and NIHR Blood and Transplant Unit in Red Cell Products, University of Bristol
- Frances Spring
- Bristol Institute for Transfusion Sciences, NHS Blood and Transplant and NIHR Blood and Transplant Unit in Red Cell Products, University of Bristol
- Piers Walser
- International Blood Group Reference Laboratory, NHS Blood and Transplant
- Abdul Ghani Alattar
- Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University
- Benjamin Jones
- International Blood Group Reference Laboratory, NHS Blood and Transplant
- Rosalind Laundy
- International Blood Group Reference Laboratory, NHS Blood and Transplant
- Jill R. Storry
- Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University
- Mattias Möller
- Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University
- Lorna Wall
- Reference Laboratory, New Zealand Blood Service
- Richard Charlewood
- Reference Laboratory, New Zealand Blood Service
- Connie M. Westhoff
- New York Blood Centre
- Christine Lomas-Francis
- New York Blood Centre
- Vered Yahalom
- Magen David Adom, National Blood Services
- Ute Feick
- Deutsches Rotes Kreuz, Blood Donor Service, Institute Bad Kreuznach
- Axel Seltsam
- German Red Cross Blood Service NSTOB, Institute Springe
- Beate Mayer
- Institute of Transfusion Medicine, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Martin L. Olsson
- Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University
- David J. Anstee
- Bristol Institute for Transfusion Sciences, NHS Blood and Transplant and NIHR Blood and Transplant Unit in Red Cell Products, University of Bristol
- DOI
- https://doi.org/10.1038/s41467-020-17060-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
The molecular basis of the clinically important MAM blood group antigen present in most humans is unknown. We identify EMP3 as its encoding gene, establishing MAM as a new blood group system, and demonstrate the role of EMP3 in erythropoiesis through its interaction with the signalling molecule CD44.
