Nature Communications (Jul 2020)

Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype

  • Nicole Thornton,
  • Vanja Karamatic Crew,
  • Louise Tilley,
  • Carole A. Green,
  • Chwen Ling Tay,
  • Rebecca E. Griffiths,
  • Belinda K. Singleton,
  • Frances Spring,
  • Piers Walser,
  • Abdul Ghani Alattar,
  • Benjamin Jones,
  • Rosalind Laundy,
  • Jill R. Storry,
  • Mattias Möller,
  • Lorna Wall,
  • Richard Charlewood,
  • Connie M. Westhoff,
  • Christine Lomas-Francis,
  • Vered Yahalom,
  • Ute Feick,
  • Axel Seltsam,
  • Beate Mayer,
  • Martin L. Olsson,
  • David J. Anstee

DOI
https://doi.org/10.1038/s41467-020-17060-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

Read online

The molecular basis of the clinically important MAM blood group antigen present in most humans is unknown. We identify EMP3 as its encoding gene, establishing MAM as a new blood group system, and demonstrate the role of EMP3 in erythropoiesis through its interaction with the signalling molecule CD44.