A cross-cohort replicable and heritable latent dimension linking behaviour to multi-featured brain structure

Eliana Nicolaisen-Sobesky; Agoston Mihalik; Shahrzad Kharabian-Masouleh; Fabio S. Ferreira; Felix Hoffstaedter; Holger Schwender; Somayeh Maleki Balajoo; Sofie L. Valk; Simon B. Eickhoff; B. T. Thomas Yeo; Janaina Mourao-Miranda; Sarah Genon

doi:10.1038/s42003-022-04244-5

Communications Biology (Nov 2022)

A cross-cohort replicable and heritable latent dimension linking behaviour to multi-featured brain structure

Eliana Nicolaisen-Sobesky,
Agoston Mihalik,
Shahrzad Kharabian-Masouleh,
Fabio S. Ferreira,
Felix Hoffstaedter,
Holger Schwender,
Somayeh Maleki Balajoo,
Sofie L. Valk,
Simon B. Eickhoff,
B. T. Thomas Yeo,
Janaina Mourao-Miranda,
Sarah Genon

Affiliations

Eliana Nicolaisen-Sobesky: Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich
Agoston Mihalik: Centre for Medical Image Computing, Department of Computer Science, University College London
Shahrzad Kharabian-Masouleh: Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich
Fabio S. Ferreira: Centre for Medical Image Computing, Department of Computer Science, University College London
Felix Hoffstaedter: Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich
Holger Schwender: Mathematical Institute, Heinrich Heine University Düsseldorf
Somayeh Maleki Balajoo: Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich
Sofie L. Valk: Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich
Simon B. Eickhoff: Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich
B. T. Thomas Yeo: Department of Electrical and Computer Engineering, Centre for Translational MR Research, Centre for Sleep & Cognition, N.1 Institute for Health, Institute for Digital Medicine, National University of Singapore
Janaina Mourao-Miranda: Centre for Medical Image Computing, Department of Computer Science, University College London
Sarah Genon: Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich

DOI: https://doi.org/10.1038/s42003-022-04244-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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Multivariate brain-behaviour associations are studied with regularized canonical correlation analysis and a machine learning framework, showing that behavioural inter-individual variability is linked to inter-individual variability in brain structure.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal