PLoS ONE (Jan 2022)

Genomic characterization of SARS-CoV-2 from vaccine breakthrough cases in Allegheny County, Pennsylvania.

  • Kady D Waggle,
  • Marissa P Griffith,
  • Lei Zhu,
  • Vaughn S Cooper,
  • Daniel J Snyder,
  • Vatsala Srinivasa,
  • Tung Phan,
  • Alan Wells,
  • Graham M Snyder,
  • Daria Van Tyne,
  • Lee H Harrison,
  • Jane W Marsh

DOI
https://doi.org/10.1371/journal.pone.0272954
Journal volume & issue
Vol. 17, no. 8
p. e0272954

Abstract

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We performed whole genome sequencing on SARS-CoV-2 from 59 vaccinated individuals from southwest Pennsylvania who tested positive between February and September, 2021. A comparison of mutations among vaccine breakthrough cases to a time-matched control group identified potential adaptive responses of SARS-CoV-2 to vaccination.