Influence of timing of prophylactic antibiotics for premature rupture of membranes on maternal and infant outcomes

Abstract

Objective To explore the influence of the timing of prophylactic antibiotic treatment for premature rupture of membranes on maternal and infant outcomes. Methods We retrospectively analyzed the data of 246 cases of low-risk premature rupture of membranes in our hospital between January, 2016 and December, 2017. According to the timing of prophylactic antibiotic treatment, the cases were divided into groups A and B with the antibiotics administered within 8 h and over 8 h, groups C and D with drug administration in 8–12 h and > 12 h, and groups E and F with administration in 12-18 h and > 18 h prior to premature rupture of membranes, respectively. The incidence of maternal infections and the maternal and infant outcomes were compared among the groups. Results No significant differences were found between groups A and B in the indicators of maternal infection either before or after the delivery or in the occurrence of adverse maternal and infant outcomes. The pH value of umbilical arterial blood was significantly higher in group C than in group D (P 18 h before delivery.

Keywords

• premature rupture of membranes
• prophylactic antibiotics
• timing
• maternal and infant outcomes