Thromboelastography in pre-surgery monitoring in Hemophilia A with high inhibitor titer: case report and literature review

Abstract

The development of factor VIII inhibitors (allo-antibodies) continues to be a major complication in the management of severe forms of hemophilia A, especially as far as treatment and treatment response monitoring is concerned. The need to implement a reliable laboratory assay is all the more obvious if major surgery occurs, when conventional tests (activated partial thromboplastin time APTT, prothrombin time PT, factor VIII level) are of no avail and there is a very fragile balance between bleeding and thrombosis.

Keywords

• severe hemophilia a
• inhibitors
• thromboelastography
• bypassing agents