Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer

Song Wu; Tong Ou; Nianzeng Xing; Jiang Lu; Shengqing Wan; Changxi Wang; Xi Zhang; Feiya Yang; Yi Huang; Zhiming Cai

doi:10.1038/s41467-019-08576-5

Nature Communications (Feb 2019)

Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer

Song Wu,
Tong Ou,
Nianzeng Xing,
Jiang Lu,
Shengqing Wan,
Changxi Wang,
Xi Zhang,
Feiya Yang,
Yi Huang,
Zhiming Cai

Affiliations

Song Wu: Urology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen University
Tong Ou: Urology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen University
Nianzeng Xing: Department of Urology, Beijing Chaoyang Hospital, Capital Medical University
Jiang Lu: Urology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen University
Shengqing Wan: Shenzhen Following Precision Medical Research Institute, Luohu Hospital Group
Changxi Wang: Urology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen University
Xi Zhang: Urology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen University
Feiya Yang: Department of Urology, Beijing Chaoyang Hospital, Capital Medical University
Yi Huang: Urology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen University
Zhiming Cai: Urology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen University

DOI: https://doi.org/10.1038/s41467-019-08576-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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Bladder cancer is one of the most common and highly vascularized cancers. Here the authors perform a whole-genome analysis in urothelial bladder carcinomas and identify recurrent genetic alterations in a set of angiogenesis genes, facilitating the understanding of molecular mechanisms underlying pathological angiogenesis in this type of cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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