Experimental evaluation of the nonselective and selective TMEM16 family calcium-activated chloride channel blockers in the airways

Abstract

The family of calcium-activated chloride channels, TMEM16, plays a significant role in contributing to the pathogenesis of airway inflammatory diseases. Targeting these ion channels and aiming to modulate them may provide an interesting new approach to the therapy of these potentially fatal diseases.

Keywords

• calcium-activated chloride channels
• tmem16a channel
• cough reflex
• bronchoconstriction
• mucociliary clearance
• guinea pigs