Nature Communications (Mar 2023)
Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation
- An Xu,
- Mo Liu,
- Mo-Fan Huang,
- Yang Zhang,
- Ruifeng Hu,
- Julian A. Gingold,
- Ying Liu,
- Dandan Zhu,
- Chian-Shiu Chien,
- Wei-Chen Wang,
- Zian Liao,
- Fei Yuan,
- Chih-Wei Hsu,
- Jian Tu,
- Yao Yu,
- Taylor Rosen,
- Feng Xiong,
- Peilin Jia,
- Yi-Ping Yang,
- Danielle A. Bazer,
- Ya-Wen Chen,
- Wenbo Li,
- Chad D. Huff,
- Jay-Jiguang Zhu,
- Francesca Aguilo,
- Shih-Hwa Chiou,
- Nathan C. Boles,
- Chien-Chen Lai,
- Mien-Chie Hung,
- Zhongming Zhao,
- Eric L. Van Nostrand,
- Ruiying Zhao,
- Dung-Fang Lee
Affiliations
- An Xu
- Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston
- Mo Liu
- Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston
- Mo-Fan Huang
- Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston
- Yang Zhang
- College of Science, Harbin Institute of Technology (Shenzhen)
- Ruifeng Hu
- Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston
- Julian A. Gingold
- Department of Obstetrics & Gynecology and Women’s Health, Einstein/Montefiore Medical Center
- Ying Liu
- Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston
- Dandan Zhu
- Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston
- Chian-Shiu Chien
- Department of Medical Research, Taipei Veterans General Hospital
- Wei-Chen Wang
- Institute of Molecular Biology, National Chung Hsing University
- Zian Liao
- Verna & Marrs McLean Department of Biochemistry & Molecular Biology and Therapeutic Innovation Center, Baylor College of Medicine
- Fei Yuan
- Verna & Marrs McLean Department of Biochemistry & Molecular Biology and Therapeutic Innovation Center, Baylor College of Medicine
- Chih-Wei Hsu
- Department of Molecular Physiology and Biophysics, Baylor College of Medicine
- Jian Tu
- Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston
- Yao Yu
- Department of Epidemiology, The University of Texas MD Anderson Cancer Center
- Taylor Rosen
- Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston
- Feng Xiong
- Department of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston
- Peilin Jia
- Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston
- Yi-Ping Yang
- Department of Medical Research, Taipei Veterans General Hospital
- Danielle A. Bazer
- Department of Neurology, Renaissance School of Medicine at Stony Brook University
- Ya-Wen Chen
- Department of Otolaryngology, Icahn School of Medicine at Mount Sinai
- Wenbo Li
- The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences
- Chad D. Huff
- The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences
- Jay-Jiguang Zhu
- Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston
- Francesca Aguilo
- Wallenberg Centre for Molecular Medicine (WCMM), Umea University
- Shih-Hwa Chiou
- Department of Medical Research, Taipei Veterans General Hospital
- Nathan C. Boles
- Neural Stem Cell Institute
- Chien-Chen Lai
- Institute of Molecular Biology, National Chung Hsing University
- Mien-Chie Hung
- Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, and Office of the President, China Medical University
- Zhongming Zhao
- The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences
- Eric L. Van Nostrand
- Verna & Marrs McLean Department of Biochemistry & Molecular Biology and Therapeutic Innovation Center, Baylor College of Medicine
- Ruiying Zhao
- Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston
- Dung-Fang Lee
- Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston
- DOI
- https://doi.org/10.1038/s41467-023-37398-9
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
The dysregulation of the m6A epitranscriptomic networks have been reported to contribute to the development of gliomas. Here, the authors utilize induced pluripotent stem cell-derived astrocytes with a p53 mutation and demonstrate that mutant p53 upregulates the m6A reader YTHDF2, resulting in the initiation of gliomas.
