CLINICAL AND MICROBIOLOGICAL EFFICACY OF ANTIBIOTIC THERAPY OF ACUTE INTESTINAL INFECTIONS WITH INVASIVE TYPE OF DIARRHEA IN CHILDREN

Abstract

In the article results of a randomized comparative multicenter study of the clinical and microbiological efficacy and safety of azithromycin (Sumamed) and cefixime (Suprax) 185 children aged 1—14 years with moderate (70.8%) and severe forms (29.2%) of acute intestinal infections with invasive type of diarrhea. Etiological diagnosis microbiological method was detected in 48 (25.9%) patients, including salmonellosis in 85.4% of cases sonnei shigellosis or Flexner in 14.6% of patients. Found that both drugs have a high clinical efficacy (of 86.2% and 87.2%, respectively). While, microbiological efficacy of azithromycin was significantly higher (83.3%) than of cefixime (58.3%) (p < 0.001), including, when salmonellosis she reached 81.8% and that of cefixime, only 52.6% of patients. A clinical study confirmed the safe use of these antimicrobial agents in the treatment of acute intestinal infections in children.

Keywords

• acute intestinal infections
• invasive diarrhea
• children
• shigellosis
• salmonellosis
• azithromycin
• cefixime
• an antibiotic therapy