Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica
Gabriela Petrișor,
Ludmila Motelica,
Denisa Ficai,
Cornelia-Ioana Ilie,
Roxana Doina Trușcǎ,
Vasile-Adrian Surdu,
Ovidiu-Cristian Oprea,
Andreea-Luiza Mȋrț,
Gabriel Vasilievici,
Augustin Semenescu,
Anton Ficai,
Lia-Mara Dițu
Affiliations
Gabriela Petrișor
Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania
Ludmila Motelica
Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania
Denisa Ficai
National Research Center for Food Safety, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania
Cornelia-Ioana Ilie
Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania
Roxana Doina Trușcǎ
Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania
Vasile-Adrian Surdu
Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania
Ovidiu-Cristian Oprea
National Research Center for Food Safety, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania
Andreea-Luiza Mȋrț
Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania
Gabriel Vasilievici
National Institute for Research & Development in Chemistry and Petrochemistry—ICECHIM, 202 Spl. Independentei, 060021 Bucharest, Romania
Augustin Semenescu
Department Engineering and Management for Transports, University POLITEHNICA of Bucharest, 060042 Bucharest, Romania
Anton Ficai
Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania
Lia-Mara Dițu
Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor, 060101 Bucharest, Romania
Two types of mesoporous materials, MCM-41 and MCM-48, were functionalized by the soft-template method using (3-aminopropyl)triethoxysilane (APTES) as a modifying agent. The obtained mesoporous silica materials were loaded with trans-ferulic acid (FA). In order to establish the morphology and structure of mesoporous materials, a series of specific techniques were used such as: X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer-Emmet-Teller (BET), Fourier Transform Infrared Spectroscopy (FTIR) and thermogravimetric analysis (TGA). We monitored the in vitro release of the loaded FA at two different pH values, by using simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Additionally, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Candida albicans ATCC 10231 were used to evaluate the antimicrobial activity of FA loaded mesoporous silica materials. In conclusion such functionalized mesoporous materials can be employed as controlled release systems for polyphenols extracted from natural sources.
