Acta Crystallographica Section E (Dec 2011)

4-[(tert-Butyldimethylsilyl)oxy]-6-methoxy-7-methyl-5-(oxiran-2-ylmethyl)-2-benzofuran-3(1H)-one

  • Magdalena Malachowska-Ugarte,
  • Grzegorz Cholewinski,
  • Jaroslaw Chojnacki,
  • Krystyna Dzierzbicka

DOI
https://doi.org/10.1107/S1600536811049026
Journal volume & issue
Vol. 67, no. 12
pp. o3393 – o3393

Abstract

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The title compound, C19H28O5Si, was obtained in the reaction of 1,3-dihydro-4-[(tert-butyldimethylsilyl)oxy]-6-methoxy-7-methyl-3-oxo-5-(prop-2-enyl)isobenzofuran with meta-chloroperbenzoic acid. This reaction is one of the stages of the total synthesis of mycophenolic acid, which we attempted to modify. The title compound forms crystals with only weak intermolecular interactions. The strongest stacking interaction is found between the benzene and furan rings of inversion-related molecules with a distance of 3.8773 (13) Å between the ring centroids.