Nature Communications (May 2020)
TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling
- Jason R. Goldsmith,
- Nina Spitofsky,
- Ali Zamani,
- Ryan Hood,
- Amanda Boggs,
- Xinyuan Li,
- Mingyue Li,
- Elizabeth Reiner,
- Arshad Ayyaz,
- Zienab Etwebi,
- Ling Lu,
- Javier Rivera Guzman,
- Mayassa J. Bou-Dargham,
- Terry Cathoupolis,
- Hakon Hakonarson,
- Honghong Sun,
- Jeffrey L. Wrana,
- Michael V. Gonzalez,
- Youhai H. Chen
Affiliations
- Jason R. Goldsmith
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Nina Spitofsky
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Ali Zamani
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Ryan Hood
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Amanda Boggs
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Xinyuan Li
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Mingyue Li
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Elizabeth Reiner
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Arshad Ayyaz
- Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Zienab Etwebi
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Ling Lu
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Javier Rivera Guzman
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Mayassa J. Bou-Dargham
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Terry Cathoupolis
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Hakon Hakonarson
- Center for Applied Genomics, The Children′s Hospital of Philadelphia
- Honghong Sun
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- Jeffrey L. Wrana
- Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
- Michael V. Gonzalez
- Center for Applied Genomics, The Children′s Hospital of Philadelphia
- Youhai H. Chen
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
- DOI
- https://doi.org/10.1038/s41467-020-16379-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 20
Abstract
The molecular mechanisms that regulate intestinal Clu+ revival stem cells (revSCs) and their niche to enable regeneration in response to injury are unclear. Here, the authors show that mice without the phospholipid transport protein, TNFAIP8, causes less revSCs to be induced following injury.
