Indian Journal of Medical and Paediatric Oncology (Dec 2024)

Fumarate Hydratase-Deficient Renal Cell Carcinoma—A Clinicopathological Study of a Series of 11 Cases

  • Aswathy A. Menon,
  • Swapnil Rane,
  • Uma Sakhadeo,
  • Gagan Prakash,
  • Amit Joshi,
  • Mahendra Pal,
  • Amandeep Arora,
  • Nilesh Sable,
  • Aparna Katdare,
  • Palak Popat,
  • Priyamvada Maitre,
  • Archi Agarwal,
  • Vedang Murthy,
  • Sangeetha B. Desai,
  • Santosh Menon

DOI
https://doi.org/10.1055/s-0043-1775804
Journal volume & issue
Vol. 45, no. 06
pp. 502 – 508

Abstract

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Introduction Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is a rare, molecularly defined renal tumor with aggressive behavior. The diagnosis of these tumors is challenging because of varied morphology and limited access to molecular testing and immunohistochemistry (IHC) for FH and 2-succinocysteine. We aim to elucidate the histomorphology, clinical presentation, and follow-up of this tumor in this first series of cases of FH-deficient RCCs from India.

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