Nature Communications (May 2017)
MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes
- Juan Pablo Lopez,
- Laura M. Fiori,
- Cristiana Cruceanu,
- Rixing Lin,
- Benoit Labonte,
- Hannah M. Cates,
- Elizabeth A. Heller,
- Vincent Vialou,
- Stacy M. Ku,
- Christophe Gerald,
- Ming-Hu Han,
- Jane Foster,
- Benicio N. Frey,
- Claudio N. Soares,
- Daniel J. Müller,
- Faranak Farzan,
- Francesco Leri,
- Glenda M. MacQueen,
- Harriet Feilotter,
- Kathrin Tyryshkin,
- Kenneth R. Evans,
- Peter Giacobbe,
- Pierre Blier,
- Raymond W. Lam,
- Roumen Milev,
- Sagar V. Parikh,
- Susan Rotzinger,
- Steven C. Strother,
- Cathryn M. Lewis,
- Katherine J. Aitchison,
- Gayle M. Wittenberg,
- Naguib Mechawar,
- Eric J. Nestler,
- Rudolf Uher,
- Sidney H. Kennedy,
- Gustavo Turecki
Affiliations
- Juan Pablo Lopez
- Department of Psychiatry, McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
- Laura M. Fiori
- Department of Psychiatry, McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
- Cristiana Cruceanu
- Department of Psychiatry, McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
- Rixing Lin
- Department of Psychiatry, McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
- Benoit Labonte
- Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Hannah M. Cates
- Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Elizabeth A. Heller
- Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Vincent Vialou
- Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Stacy M. Ku
- Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Christophe Gerald
- Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Ming-Hu Han
- Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Jane Foster
- Department of Psychiatry, University Health Network, University of Toronto
- Benicio N. Frey
- McMaster University and St Joseph’s Healthcare Hamilton
- Claudio N. Soares
- St Michael’s Hospital
- Daniel J. Müller
- Department of Psychiatry, University Health Network, University of Toronto
- Faranak Farzan
- Department of Psychiatry, University Health Network, University of Toronto
- Francesco Leri
- University of Guelph
- Glenda M. MacQueen
- University of Calgary Hotchkiss Brain Institute
- Harriet Feilotter
- Department of Pathology and Molecular Medicine, Queen’s University
- Kathrin Tyryshkin
- Department of Pathology and Molecular Medicine, Queen’s University
- Kenneth R. Evans
- Department of Pathology and Molecular Medicine, Queen’s University
- Peter Giacobbe
- Department of Psychiatry, University Health Network, University of Toronto
- Pierre Blier
- University of Ottawa Institute of Mental Health Research
- Raymond W. Lam
- University of British Columbia and Vancouver Coastal Health Authority
- Roumen Milev
- Queen’s University, Providence Care, Mental Health Services
- Sagar V. Parikh
- University of Michigan
- Susan Rotzinger
- Department of Psychiatry, University Health Network, University of Toronto
- Steven C. Strother
- Rotman Research Institute at Baycrest Centre
- Cathryn M. Lewis
- MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
- Katherine J. Aitchison
- Departments of Psychiatry and Medical Genetics, University of Alberta
- Gayle M. Wittenberg
- Janssen Research & Development, LLC
- Naguib Mechawar
- Department of Psychiatry, McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
- Eric J. Nestler
- Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Rudolf Uher
- MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
- Sidney H. Kennedy
- Department of Psychiatry, University Health Network, University of Toronto
- Gustavo Turecki
- Department of Psychiatry, McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
- DOI
- https://doi.org/10.1038/ncomms15497
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Antidepressant drugs are the most common treatment for depressive episodes but only a fraction of patients experience adequate response. Here the authors find dysregulation of miRNAs in peripheral blood samples from depressed patients after antidepressant treatment, and show that the miRNAs are regulators of psychiatrically relevant signalling pathways.
