Nature Communications (May 2022)
Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C
- Juanjie Tang,
- Tanya Novak,
- Julian Hecker,
- Gabrielle Grubbs,
- Fatema Tuz Zahra,
- Lorenza Bellusci,
- Sara Pourhashemi,
- Janet Chou,
- Kristin Moffitt,
- Natasha B. Halasa,
- Stephanie P. Schwartz,
- Tracie C. Walker,
- Keiko M. Tarquinio,
- Matt S. Zinter,
- Mary A. Staat,
- Shira J. Gertz,
- Natalie Z. Cvijanovich,
- Jennifer E. Schuster,
- Laura L. Loftis,
- Bria M. Coates,
- Elizabeth H. Mack,
- Katherine Irby,
- Julie C. Fitzgerald,
- Courtney M. Rowan,
- Michele Kong,
- Heidi R. Flori,
- Aline B. Maddux,
- Steven L. Shein,
- Hillary Crandall,
- Janet R. Hume,
- Charlotte V. Hobbs,
- Adriana H. Tremoulet,
- Chisato Shimizu,
- Jane C. Burns,
- Sabrina R. Chen,
- Hye Kyung Moon,
- Christoph Lange,
- Adrienne G. Randolph,
- Surender Khurana
Affiliations
- Juanjie Tang
- Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA
- Tanya Novak
- Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital
- Julian Hecker
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Gabrielle Grubbs
- Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA
- Fatema Tuz Zahra
- Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA
- Lorenza Bellusci
- Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA
- Sara Pourhashemi
- Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA
- Janet Chou
- Department of Pediatrics, Boston Children’s Hospital and Harvard Medical School
- Kristin Moffitt
- Department of Pediatrics, Boston Children’s Hospital and Harvard Medical School
- Natasha B. Halasa
- Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center
- Stephanie P. Schwartz
- Department of Pediatrics, University of North Carolina at Chapel Hill Children’s Hospital
- Tracie C. Walker
- Department of Pediatrics, University of North Carolina at Chapel Hill Children’s Hospital
- Keiko M. Tarquinio
- Division of Critical Care Medicine, Department of Pediatrics, Emory University School of Medicine, Children’s Healthcare of Atlanta
- Matt S. Zinter
- Department of Pediatrics, Divisions of Critical Care and Bone Marrow Transplantation, University of California, San Francisco
- Mary A. Staat
- Department of Pediatrics, University of Cincinnati, Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center
- Shira J. Gertz
- Division of Pediatric Critical Care, Department of Pediatrics, Cooperman Barnabas Medical Center
- Natalie Z. Cvijanovich
- Division of Critical Care Medicine, UCSF Benioff Children’s Hospital Oakland
- Jennifer E. Schuster
- Division of Pediatric Infectious Diseases, Department of Pediatrics, Children’s Mercy Kansas City
- Laura L. Loftis
- Division of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine
- Bria M. Coates
- Division of Critical Care Medicine, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago
- Elizabeth H. Mack
- Division of Pediatric Critical Care Medicine, Medical University of South Carolina
- Katherine Irby
- Section of Pediatric Critical Care, Department of Pediatrics, Arkansas Children’s Hospital
- Julie C. Fitzgerald
- Division of Critical Care, Department of Anesthesiology and Critical Care, The University of Pennsylvania Perelman School of Medicine
- Courtney M. Rowan
- Division of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children
- Michele Kong
- Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Alabama at Birmingham
- Heidi R. Flori
- Division of Pediatric Critical Care Medicine, Department of Pediatrics, Mott Children’s Hospital and University of Michigan
- Aline B. Maddux
- Department of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine and Children’s Hospital Colorado
- Steven L. Shein
- Division of Pediatric Critical Care Medicine, Rainbow Babies and Children’s Hospital
- Hillary Crandall
- Division of Pediatric Critical Care, Department of Pediatrics, University of Utah
- Janet R. Hume
- Division of Pediatric Critical Care, University of Minnesota Masonic Children’s Hospital
- Charlotte V. Hobbs
- Department of Pediatrics, Department of Microbiology, Division of Infectious Diseases, University of Mississippi Medical Center
- Adriana H. Tremoulet
- Kawasaki Disease Research Center, Rady Children’s Hospital and Department of Pediatrics, UCSD School of Medicine
- Chisato Shimizu
- Kawasaki Disease Research Center, Rady Children’s Hospital and Department of Pediatrics, UCSD School of Medicine
- Jane C. Burns
- Kawasaki Disease Research Center, Rady Children’s Hospital and Department of Pediatrics, UCSD School of Medicine
- Sabrina R. Chen
- Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital
- Hye Kyung Moon
- Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital
- Christoph Lange
- Department of Biostatistics, Harvard T.H. Chan School of Public Health
- Adrienne G. Randolph
- Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital
- Surender Khurana
- Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA
- DOI
- https://doi.org/10.1038/s41467-022-30649-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
The antibody response to the SARS-CoV-2 Omicron variant is not well studied in children. Here, the authors provide an age-stratified analysis of SARS-CoV-2 neutralizing capacity of sera from children with acute or convalescent COVID-19 as well as children with multisystem inflammatory syndrome.
