Precise temporal regulation of alternative splicing during neural development

Sebastien M. Weyn-Vanhentenryck; Huijuan Feng; Dmytro Ustianenko; Rachel Duffié; Qinghong Yan; Martin Jacko; Jose C. Martinez; Marianne Goodwin; Xuegong Zhang; Ulrich Hengst; Stavros Lomvardas; Maurice S. Swanson; Chaolin Zhang

doi:10.1038/s41467-018-04559-0

Nature Communications (Jun 2018)

Precise temporal regulation of alternative splicing during neural development

Sebastien M. Weyn-Vanhentenryck,
Huijuan Feng,
Dmytro Ustianenko,
Rachel Duffié,
Qinghong Yan,
Martin Jacko,
Jose C. Martinez,
Marianne Goodwin,
Xuegong Zhang,
Ulrich Hengst,
Stavros Lomvardas,
Maurice S. Swanson,
Chaolin Zhang

Affiliations

Sebastien M. Weyn-Vanhentenryck: Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University
Huijuan Feng: Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University
Dmytro Ustianenko: Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University
Rachel Duffié: Department of Biochemistry and Molecular Biophysics, Mortimer B. Zuckerman Mind Brain and Behavior Institute, Columbia University
Qinghong Yan: Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University
Martin Jacko: Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University
Jose C. Martinez: Department of Pathology and Cell Biology, The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University
Marianne Goodwin: Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine
Xuegong Zhang: Department of Automation, MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST, Tsinghua University
Ulrich Hengst: Department of Pathology and Cell Biology, The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University
Stavros Lomvardas: Department of Biochemistry and Molecular Biophysics, Mortimer B. Zuckerman Mind Brain and Behavior Institute, Columbia University
Maurice S. Swanson: Department of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida, College of Medicine
Chaolin Zhang: Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University

DOI: https://doi.org/10.1038/s41467-018-04559-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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The precise timing of neurodevelopmental splicing switches and the underlying regulatory mechanisms remain poorly understood. This study identifies two major waves of developmental switches under the control of distinct combinations of RNA-binding proteins in central and peripheral nervous systems.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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