CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson’s disease

Maximilian Frosch; Lukas Amann; Marco Prinz

doi:10.1038/s41467-023-39061-9

Nature Communications (Jun 2023)

CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson’s disease

Maximilian Frosch,
Lukas Amann,
Marco Prinz

Affiliations

Maximilian Frosch: Faculty of Medicine, Institute of Neuropathology, University of Freiburg
Lukas Amann: Faculty of Medicine, Institute of Neuropathology, University of Freiburg
Marco Prinz: Faculty of Medicine, Institute of Neuropathology, University of Freiburg

DOI: https://doi.org/10.1038/s41467-023-39061-9
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 3

Abstract

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In an alpha-synuclein (α-syn) model of Parkinson’s disease (PD), Schonhoff and colleagues have shown that central nervous system (CNS)-associated macrophages (CAMs), but not microglia, potentially orchestrate CD4+ T cell recruitment and mediate an α-syn-induced inflammatory makeup.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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