International Journal of Molecular Sciences (May 2021)

AT1 and AT2 Receptor Knockout Changed Osteonectin and Bone Density in Mice in Periodontal Inflammation Experimental Model

  • Maria Laura de Souza Lima,
  • Caroline Addison Carvalho Xavier de Medeiros,
  • Gerlane Coelho Bernardo Guerra,
  • Robson Santos,
  • Michael Bader,
  • Flavia Q. Pirih,
  • Raimundo Fernandes de Araújo Júnior,
  • Alan B. Chan,
  • Luis J. Cruz,
  • Gerly Anne de Castro Brito,
  • Renata Ferreira de Carvalho Leitão,
  • Ericka Janine Dantas da Silveira,
  • Vinicius Barreto Garcia,
  • Agnes Andrade Martins,
  • Aurigena Antunes de Araújo

DOI
https://doi.org/10.3390/ijms22105217
Journal volume & issue
Vol. 22, no. 10
p. 5217

Abstract

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Background: The aim of this study was to evaluate the role of AT1 and AT2 receptors in a periodontal inflammation experimental model. Methods: Periodontal inflammation was induced by LPS/Porphyromonas gingivalis. Maxillae, femur, and vertebra were scanned using Micro-CT. Maxillae were analyzed histopathologically, immunohistochemically, and by RT-PCR. Results: The vertebra showed decreased BMD in AT1 H compared with WT H (p p p p p p p p p p p p p < 0.01). Conclusion: AT1 receptor knockout changed bone density, the quality and number of bone trabeculae, decreased the number of osteoblast cells, and increased osteonectin in fibroblasts.

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