A New Megastigmane Glucoside and Other Constituents from Desmodium gangeticum

Hau Viet Dang; Giang Hoang Do; Phuong Thi Ngo; Tien Dat Nguyen; Ha Minh Le

doi:10.1155/2020/7416973

Journal of Chemistry (Jan 2020)

A New Megastigmane Glucoside and Other Constituents from Desmodium gangeticum

Hau Viet Dang,
Giang Hoang Do,
Phuong Thi Ngo,
Tien Dat Nguyen,
Ha Minh Le

Affiliations

Hau Viet Dang: Center for Research and Technology Transfer, Vietnam Academy of Science and Technology (VAST), 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
Giang Hoang Do: Center for Research and Technology Transfer, Vietnam Academy of Science and Technology (VAST), 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
Phuong Thi Ngo: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
Tien Dat Nguyen: Center for Research and Technology Transfer, Vietnam Academy of Science and Technology (VAST), 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
Ha Minh Le: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

DOI: https://doi.org/10.1155/2020/7416973
Journal volume & issue: Vol. 2020

Abstract

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A new megastigmane glycoside, gangeticoside (1), and three known compounds leonuriside A (2), methyl benzoate 2-O-β-D-glucopyranoside (3), and tortoside A (4) were isolated from the aerial part of Desmodium gangeticum. Their structures were determined by 1D and 2D NMR spectra. The isolated compounds were evaluated for their inhibitory effect on NO production in LPS-stimulated RAW264.7 cells. Among them, compounds 1, 2, and 3 exhibited strong effect with the IC50 values of 22.3, 15.6, 7.3 μM, respectively.

Published in Journal of Chemistry

ISSN: 2090-9063 (Print); 2090-9071 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://onlinelibrary.wiley.com/journal/2962

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