Nature Communications (Jan 2020)
In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits
- Xiangbo Ruan,
- Ping Li,
- Yi Chen,
- Yu Shi,
- Mehdi Pirooznia,
- Fayaz Seifuddin,
- Hiroshi Suemizu,
- Yasuyuki Ohnishi,
- Nao Yoneda,
- Megumi Nishiwaki,
- James Shepherdson,
- Abhilash Suresh,
- Komudi Singh,
- Yonghe Ma,
- Cheng-fei Jiang,
- Haiming Cao
Affiliations
- Xiangbo Ruan
- Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health
- Ping Li
- Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health
- Yi Chen
- Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health
- Yu Shi
- Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health
- Mehdi Pirooznia
- Bioinformatics and Computational Biology Core, National Heart Lung and Blood Institute, National Institutes of Health
- Fayaz Seifuddin
- Bioinformatics and Computational Biology Core, National Heart Lung and Blood Institute, National Institutes of Health
- Hiroshi Suemizu
- Laboratory Animal Research Department, Biomedical Research Laboratory, Central Institute for Experimental Animals
- Yasuyuki Ohnishi
- Laboratory Animal Research Department, Biomedical Research Laboratory, Central Institute for Experimental Animals
- Nao Yoneda
- Laboratory Animal Research Department, Biomedical Research Laboratory, Central Institute for Experimental Animals
- Megumi Nishiwaki
- Laboratory Animal Research Department, Biomedical Research Laboratory, Central Institute for Experimental Animals
- James Shepherdson
- Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health
- Abhilash Suresh
- Bioinformatics and Computational Biology Core, National Heart Lung and Blood Institute, National Institutes of Health
- Komudi Singh
- Bioinformatics and Computational Biology Core, National Heart Lung and Blood Institute, National Institutes of Health
- Yonghe Ma
- Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health
- Cheng-fei Jiang
- Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health
- Haiming Cao
- Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-019-13688-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Majority of human long non-coding RNAs (lncRNAs) are not conserved in mouse. Here the authors identify metabolic trait-associated lncRNA genes and show a functional role of a non-conserved human lncRNA, LINC01018, in lipid metabolism using a humanized mouse model.
