Transient interactions drive the lateral clustering of cadherin-23 on membrane

Cheerneni S. Srinivas; Gayathri S. Singaraju; Veerpal Kaur; Sayan Das; Sanat K. Ghosh; Amin Sagar; Anuj Kumar; Tripta Bhatia; Sabyasachi Rakshit

doi:10.1038/s42003-023-04677-6

Communications Biology (Mar 2023)

Transient interactions drive the lateral clustering of cadherin-23 on membrane

Cheerneni S. Srinivas,
Gayathri S. Singaraju,
Veerpal Kaur,
Sayan Das,
Sanat K. Ghosh,
Amin Sagar,
Anuj Kumar,
Tripta Bhatia,
Sabyasachi Rakshit

Affiliations

Cheerneni S. Srinivas: Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali
Gayathri S. Singaraju: Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali
Veerpal Kaur: Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali
Sayan Das: Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali
Sanat K. Ghosh: Department of Physical Sciences, Indian Institute of Science Education and Research Mohali
Amin Sagar: Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali
Anuj Kumar: Department of Physical Sciences, Indian Institute of Science Education and Research Mohali
Tripta Bhatia: Department of Physical Sciences, Indian Institute of Science Education and Research Mohali
Sabyasachi Rakshit: Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali

DOI: https://doi.org/10.1038/s42003-023-04677-6
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 11

Abstract

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The long non-classical cadherin-23 forms cis-clusters on a membrane via transient, weak, but multivalent and spatially distributed hydrophobic interactions.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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