Nature Communications (Oct 2019)
Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
- Fengjie Huang,
- Xiaojiao Zheng,
- Xiaohui Ma,
- Runqiu Jiang,
- Wangyi Zhou,
- Shuiping Zhou,
- Yunjing Zhang,
- Sha Lei,
- Shouli Wang,
- Junliang Kuang,
- Xiaolong Han,
- Meilin Wei,
- Yijun You,
- Mengci Li,
- Yitao Li,
- Dandan Liang,
- Jiajian Liu,
- Tianlu Chen,
- Chao Yan,
- Runmin Wei,
- Cynthia Rajani,
- Chengxing Shen,
- Guoxiang Xie,
- Zhaoxiang Bian,
- Houkai Li,
- Aihua Zhao,
- Wei Jia
Affiliations
- Fengjie Huang
- Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Xiaojiao Zheng
- Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Xiaohui Ma
- Department of Pharmacology and Toxicology, Tasly Pharmaceutical Co. Ltd
- Runqiu Jiang
- University of Hawaii Cancer Center
- Wangyi Zhou
- Department of Pharmacology and Toxicology, Tasly Pharmaceutical Co. Ltd
- Shuiping Zhou
- Department of Pharmacology and Toxicology, Tasly Pharmaceutical Co. Ltd
- Yunjing Zhang
- Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Sha Lei
- Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Shouli Wang
- Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Junliang Kuang
- Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Xiaolong Han
- Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Meilin Wei
- Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Yijun You
- Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Mengci Li
- Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Yitao Li
- Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Dandan Liang
- Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Jiajian Liu
- Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Tianlu Chen
- Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Chao Yan
- School of Pharmacy, Shanghai Jiao Tong University
- Runmin Wei
- University of Hawaii Cancer Center
- Cynthia Rajani
- University of Hawaii Cancer Center
- Chengxing Shen
- Department of Cardiology, Shanghai Jiao Tong University Affiliated Six People’s Hospital
- Guoxiang Xie
- University of Hawaii Cancer Center
- Zhaoxiang Bian
- Chinese Medicine Clinical Study Center, School of Chinese Medicine, Hong Kong Baptist University
- Houkai Li
- Functional Metabolomic and Gut Microbiome Laboratory, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine
- Aihua Zhao
- Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Wei Jia
- Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- DOI
- https://doi.org/10.1038/s41467-019-12896-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Pu-erh tea displays cholesterol-lowering properties. Here, Huang et al. show that this is mostly due to the action of a pigment in Pu-erh tea that induces changes in certain gut microbiota and bile acid levels, thus modulating the gut-liver metabolic axis.
