The embryology and molecular-genetic mechanisms of brain tumor pathogenesis: literature review

Abstract

The literature review describes molecular-genetic changes in adults and children’s brain tumors which are diagnosed most often. The results of the published data show considerable heterogeneity and differences of these changes depending on the type of a tumor, period of research, and the age of patients. Identification of dominant molecular rearrangements in a particular patient at a certain stage of carcinogenesis helps customize the selection and enhance the effect of treatment by determining the priority of potential targets for differentiated influence.