Frontiers in Public Health (Dec 2022)

Design and recruitment of a large-scale cohort study on prevalence, risk factors and impact evaluation of post-COVID-19 condition and its wider long-term social, mental, and physical health impact: The PRIME post-COVID study

  • Demi M. E. Pagen,
  • Demi M. E. Pagen,
  • Céline J. A. van Bilsen,
  • Céline J. A. van Bilsen,
  • Stephanie Brinkhues,
  • Chrissy P. B. Moonen,
  • Chrissy P. B. Moonen,
  • Maarten Van Herck,
  • Maarten Van Herck,
  • Maarten Van Herck,
  • Kevin Konings,
  • Casper D. J. den Heijer,
  • Casper D. J. den Heijer,
  • Suhreta Mujakovic,
  • Henriëtte L. G. ter Waarbeek,
  • Noortje Bouwmeester-Vincken,
  • Anouk W. Vaes,
  • Martijn A. Spruit,
  • Martijn A. Spruit,
  • Christian J. P. A. Hoebe,
  • Christian J. P. A. Hoebe,
  • Christian J. P. A. Hoebe,
  • Nicole H. T. M. Dukers-Muijrers,
  • Nicole H. T. M. Dukers-Muijrers

DOI
https://doi.org/10.3389/fpubh.2022.1032955
Journal volume & issue
Vol. 10

Abstract

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BackgroundPersistent symptoms, described as long COVID or post-COVID-19 condition, pose a potential public health problem. Here, the design and recruitment of the PRIME post-COVID study is described. PRIME post-COVID is a large-scale population-based observational study that aims to improve understanding of the occurrence, risk factors, social, physical, mental, emotional, and socioeconomic impact of post-COVID-19 condition.MethodsAn observational open cohort study was set up, with retrospective and prospective assessments on various health-conditions and health-factors (medical, demographic, social, and behavioral) based on a public health COVID-19 test and by self-report (using online questionnaires in Dutch language). Invited for participation were, as recorded in a public health registry, adults (18 years and older) who were tested for COVID-19 and had a valid Polymerase Chain Reaction (PCR) positive or negative test result, and email address. In November 2021, 61,655 individuals were invited by email to participate, these included all eligible adults who tested PCR positive between 1 June 2020 and 1 November 2021, and a sample of adults who tested negative (2:1), comparable in distribution of age, sex, municipality of residence and year-quarter of testing. New recruitment periods are planned as well. Participants are followed over time by regular follow-up measurements. Data are analyzed using the appropriate data-analyses methods.DiscussionThe PRIME post-COVID study will provide insights into various health-related aspects of post-COVID-19 condition in the context of various stages of the COVID-19 pandemic. Results will inform practical guidance for society, clinical and public health practice for the prevention and care for long-term impact of COVID-19.Trial registration ClinicalTrials.gov identifierNCT05128695.

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