Nature Communications (Sep 2022)
Rtt105 regulates RPA function by configurationally stapling the flexible domains
- Sahiti Kuppa,
- Jaigeeth Deveryshetty,
- Rahul Chadda,
- Jenna R. Mattice,
- Nilisha Pokhrel,
- Vikas Kaushik,
- Angela Patterson,
- Nalini Dhingra,
- Sushil Pangeni,
- Marisa K. Sadauskas,
- Sajad Shiekh,
- Hamza Balci,
- Taekjip Ha,
- Xiaolan Zhao,
- Brian Bothner,
- Edwin Antony
Affiliations
- Sahiti Kuppa
- Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine
- Jaigeeth Deveryshetty
- Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine
- Rahul Chadda
- Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine
- Jenna R. Mattice
- Department of Chemistry and Biochemistry, Montana State University
- Nilisha Pokhrel
- Department of Biological Sciences, Marquette University
- Vikas Kaushik
- Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine
- Angela Patterson
- Department of Chemistry and Biochemistry, Montana State University
- Nalini Dhingra
- Molecular Biology Department, Memorial Sloan Kettering Cancer Center
- Sushil Pangeni
- Department of Biophysics, Johns Hopkins University
- Marisa K. Sadauskas
- Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine
- Sajad Shiekh
- Department of Physics, Kent State University
- Hamza Balci
- Department of Physics, Kent State University
- Taekjip Ha
- Department of Biophysics, Johns Hopkins University
- Xiaolan Zhao
- Molecular Biology Department, Memorial Sloan Kettering Cancer Center
- Brian Bothner
- Department of Chemistry and Biochemistry, Montana State University
- Edwin Antony
- Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-32860-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
The single stranded DNA binding protein RPA coordinates DNA metabolism using multiple protein and DNA interaction domains. Here, the authors show that the chaperone-like protein Rtt105 staples RPA domains to prevent untimely protein interactions.
