International Journal of Nanomedicine (Nov 2018)
Sub-10 nm Cu5FeS4 cube for magnetic resonance imaging-guided photothermal therapy of cancer
Abstract
Dan Wang,1 Yuwen Zhang,1 Qi Guo2 1Department of Pathology, The First People’s Hospital of Shangqiu, Shangqiu, Henan 476000, China; 2Department of Orthopedics, The First People’s Hospital of Shangqiu, Shangqiu, Henan 476000, China Background: Facile synthesis and small size theranostic agents have shown great potential for cancer diagnosis and treatment. Purpose: A ternary compound (Cu5FeS4), Fe doped copper sulfide, with novel magnetic properties and strong near-infrared absorption was prepared for magnetic resonance imaging (MRI) imaging guided photothermal therapy of cancer.Patients and methods: Firstly, the capability of magnetic resonance imaging based on the novel magnetic properties and the photothermal performance due to the strong near-infrared absorption was investigated in vitro. Then, the magnetic resonance imaging guided photothermal therapy for 4T1 tumor-bearing mouse was carried out.Results: The Cu5FeS4 cube with good T1-weighted MRI, excellent photothermal performance and low cytotoxicity has been investigated. More importantly, the T1-weighted MRI for 4T1 tumor-bearing mouse will get the best contrast effect at tumor site after 8 h of intravenous injection of Cu5FeS4 cube. Under the guidance of the T1-weighted MRI, the PTT was carried out at 8 h after intravenous injection of Cu5FeS4 cube and only the group combined intravenous administration of Cu5FeS4 cube and laser irradiation nearly cured the tumor after 14 days.Conclusion: Our study not only provides a new material for personalized treatment of tumors, but also further promotes potential applications of the cancer theranostic agents. Keywords: magnetic nanoparticle, imaging, theranostic, 4T1, ultra-small
