Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4

Ning Lu; Ying Li; Zhiqiang Zhang; Junji Xing; Ying Sun; Sheng Yao; Lieping Chen

doi:10.1038/s41467-018-03128-9

Nature Communications (Feb 2018)

Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4

Ning Lu,
Ying Li,
Zhiqiang Zhang,
Junji Xing,
Ying Sun,
Sheng Yao,
Lieping Chen

Affiliations

Ning Lu: CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences
Ying Li: CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences
Zhiqiang Zhang: Department of Immunology and Center for Cancer Immunology Research, The University of Texas M.D. Anderson Cancer Center
Junji Xing: Immunobiology and Transplant Research, Houston Methodist Hospital and Methodist Hospital Research Institute, Texas Medical Center
Ying Sun: Division of Asthma, Allergy and Lung Biology, MRC-Asthma UK Centre for Allergic Mechanisms of Asthma, King’s College London
Sheng Yao: Department of Immunobiology, Medicine and Dermatology, Cancer Immunology Program at Yale Cancer Center, Yale University School of Medicine
Lieping Chen: Department of Immunobiology, Medicine and Dermatology, Cancer Immunology Program at Yale Cancer Center, Yale University School of Medicine

DOI: https://doi.org/10.1038/s41467-018-03128-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Semaphorin-4A is a cell surface protein with known functions in neural development and immune regulation, but the mechanism for immune modulation is unclear. Here the authors show that ILT-4, previously found on myeloid cells, is the receptor of Semaphorin-4A on activate human CD4 T cells for mediating T cell co-stimulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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