Nature Communications (Nov 2022)

Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB

  • Meghan H. Murray,
  • Aurore Cecile Valfort,
  • Thomas Koelblen,
  • Céline Ronin,
  • Fabrice Ciesielski,
  • Arindam Chatterjee,
  • Giri Babu Veerakanellore,
  • Bahaa Elgendy,
  • John K. Walker,
  • Lamees Hegazy,
  • Thomas P. Burris

DOI
https://doi.org/10.1038/s41467-022-34892-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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The nuclear receptor REV-ERBα is a receptor for heme and plays a role in a range of physiological processes. Here, the authors provide the first structure of REV-ERB bound to a synthetic nonporphyrin ligand defining key mechanistic differences to how heme binds.