Evaluation of the time-dependent effects of factors influencing the hazard of disease recurrence in tuberculosis patients

Mehdi Kazempour Dizaji; Mohammad Varahram; Atefe Abedini; Rahim Roozbahani; Ali Zare; Payam Tabarsi; Majid Marjani; Afshin Moniri; Niloufar Alizadeh Kolahdozi; Mohammadreza Madani; Parvaneh Baghaei Shiva

Health Science Monitor (Jan 2024)

Evaluation of the time-dependent effects of factors influencing the hazard of disease recurrence in tuberculosis patients

Mehdi Kazempour Dizaji,
Mohammad Varahram,
Atefe Abedini,
Rahim Roozbahani,
Ali Zare,
Payam Tabarsi,
Majid Marjani,
Afshin Moniri,
Niloufar Alizadeh Kolahdozi,
Mohammadreza Madani,
Parvaneh Baghaei Shiva

Affiliations

Mehdi Kazempour Dizaji: Mycobacteriology Research Center (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohammad Varahram: Mycobacteriology Research Center (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Atefe Abedini: Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Rahim Roozbahani: Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ali Zare: Department of Biostatistics, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Payam Tabarsi: Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Majid Marjani: Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Afshin Moniri: Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Niloufar Alizadeh Kolahdozi: Department of Biostatistics, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohammadreza Madani: Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Parvaneh Baghaei Shiva: Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

Journal volume & issue: Vol. 3, no. 1
pp. 39 – 47

Abstract

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Background & Aims: There are variables whose influence on the risk of tuberculosis (TB) recurrence change over time. Therefore, this study aimed to assess the time-dependent effects of these variables on the hazard of TB recurrence. Materials & Methods: In this historical cohort study, data were collected from 4,564 TB patients who were referred to the TB research center of Dr. Masih Daneshvari Hospital, Tehran, from 2005 to 2015, in order to evaluate factors affecting the hazard of TB recurrence in terms of time dependency or time constancy. Data were analyzed in STATA 14 software using a statistical test based on Schoenfeld residuals, the time-dependent effects method, and the time-varying effects model (considering time function as f (t) = t). Results: The results showed that only the impact of the variables of drug adverse effects and passive smoker were inconstant over time and had time-dependent effects, and they also influenced the hazard of TB recurrence. Also, the effect of the two mentioned variables on the hazard of TB recurrence displayed a decreasing and increasing trend with time, respectively. Conclusion: Using the time-varying effects model in the study of the hazard of TB recurrence allows evaluating the time-dependent effects of the studied variables and also can differentiate them from the time-independent variables.

Published in Health Science Monitor

ISSN: 2980-8723 (Online)
Publisher: Urmia University of Medical Sciences
Country of publisher: Iran, Islamic Republic of
LCC subjects: Medicine
Website: http://hsm.umsu.ac.ir/

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