Nature Communications (Dec 2018)

Local and global chromatin interactions are altered by large genomic deletions associated with human brain development

  • Xianglong Zhang,
  • Ying Zhang,
  • Xiaowei Zhu,
  • Carolin Purmann,
  • Michael S. Haney,
  • Thomas Ward,
  • Arineh Khechaduri,
  • Jie Yao,
  • Sherman M. Weissman,
  • Alexander E. Urban

DOI
https://doi.org/10.1038/s41467-018-07766-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Copy number variants in the human genome (CNVs) are associated with neurodevelopmental and psychiatric disorders such as schizophrenia and autism. Here the authors investigate how the large deletion CNV on chromosome 22q11.2 alters chromatin organization.