Arquivo Brasileiro de Medicina Veterinária e Zootecnia (Jul 2020)

Effect of nabumetone on humoral immune responses in mice

  • Khalid Naveed,
  • Aqeel Javeed,
  • Muhammad Ashraf,
  • Amjad Riaz,
  • Aamir Ghafoor,
  • Adeel Sattar

DOI
https://doi.org/10.1590/1678-4162-11460
Journal volume & issue
Vol. 72, no. 3
pp. 915 – 920

Abstract

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ABSTRACT Nabumetone is used to reduce the pain and inflammation in rheumatoid arthritis. In the current study, immunomodulatory effect of Nabumetone is investigated in mice. The control group was administered normal saline orally as placebo. Nabumetone was administered orally via gavage in two treatment groups at 14mg/kg.b.w. doses and 28mg/kgb.w., respectively. Haemagglutination (HA) assay, Jerne hemolytic plaque and mice lethality assays were applied. In HA assay, the titer was significantly decreased in Nabumetone treatment groups (P< 0.001). In Jerne hemolytic plaque formation assay, there was a significant reduction (P< 0.001) in number of plaques in Nabumetone treated groups when compared with control. In mice lethality assay, there was a significant difference in mortality ratio of mice in control and Nabumetone treated groups (P< 0.001). Therefore, it is concluded that Nabumetone suppresses the humoral immune response in mice.

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