Association of Thyroid Hormones with Oxidative Stress Markers in Patient with Hyperthyroidism

Abstract

Background: Biomarkers for diagnosing the occurrence and development of hyperthyroidism constitute a major worldwide clinical scrutiny. Evidence is continuing in an investigation about the most relevant biomarkers in developing the disease. Objective: To discover and correlate the most dependent biomarkers in developing hyperthyroidism in both genders. Patients and Methods: In the present study, two groups were included, the first group: forty males and females with chronic hyperthyroidism were enrolled. Serum levels of thyroid hormones, lipid profile, oxidative stress marker, blood glucose, and renal function markers were measured and compared with euthyroid subjects. Results: The present study revealed that referral biomarkers were varied between genders with a remarkable association of hyperthyroidism with serum cholesterol, triglycerides, and low-density lipoproteins in females, while nitrites and creatinine and MDA were significantly correlated in male patients. Conclusion: In this study, we found that indicating biomarkers for hyperthyroidism could be differentially changed in different genders that help in understanding the progression and development of the disease.

Keywords

• Hyperthyroidism, oxidative stress, malondialdehyde, creatinine, nitrite.