Frontiers in Endocrinology (Jul 2022)

Case Report: Insulinoma Co-Existing With Type 2 Diabetes – Advantages and Challenges of Treatment With Endoscopic Ultrasound-Guided Radiofrequency Ablation

  • Johnny Yau-Cheung Chang,
  • Chariene Shao-Lin Woo,
  • David Tak-Wai Lui,
  • Matrix Man-Him Fung,
  • Alan Chun-Hong Lee,
  • Eunice Ka-Hong Leung,
  • Yu-Cho Woo,
  • Wing-Sun Chow,
  • Karen Siu-Ling Lam,
  • Kathryn Choon-Beng Tan,
  • Chi-Ho Lee

DOI
https://doi.org/10.3389/fendo.2022.957369
Journal volume & issue
Vol. 13

Abstract

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The coexistence of insulinoma and type 2 diabetes is rare and the diagnostic process is often challenging. Continuous glucose monitoring system devices, which are more readily available nowadays, provide a useful tool for the diagnosis and evaluation of treatment response. Curative surgery is often the mainstay of treatment for insulinoma. Here, we report a Chinese patient with insulinoma diagnosed simultaneously with type 2 diabetes. His insulinoma was managed with endoscopic ultrasound guided-radiofrequency ablation (EUS-RFA) and the patient achieved complete resolution of hypoglycaemic episodes. The case illustrates that while EUS-RFA is an emerging non-invasive treatment modality for pancreatic lesions, limitations exist especially when histological confirmation is essential.

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